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P. David Adelson, MD, FAANS— Despite improved outcomes with decreased mortality, trauma and in particular traumatic brain injury (TBI) continues to be the leading cause of death and disability in children and young adults. While there have been many factors that have contributed to these improved outcomes following TBI (i.e. injury prevention programs, safety equipment, improved ICU management, etc.), there have been a number of challenges with regards to the study of TBI that has led to introspection on the part of those investigators looking for the next generation of novel therapeutic interventions. Part of this self-analysis comes
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