Nir Lipsman, MD; and Andres M. Lozano, MD, PhD, FAANS— There have been more than 80,000 patients worldwide who have received deep brain stimulation (DBS) to treat Parkinson’s disease, dystonia and tremor. The realization of the striking efficacy of this therapy and its long record of safety, together with the increased understanding of the neurobiological basis and circuitry of psychiatric disorders, has led to DBS now being examined as a potential therapy in depression.There is a great need to develop novel therapies for depression as the condition remains one of the leading causes of morbidity and mortality in the western world affecting more than 100 million people globally.
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